Cyclosporine A (CsA) shows significant inter‐individual variability in its pharmacokinetics,
which may be due to polymorphisms in ABCB‐1 genes coding for P‐glycoprotein. The aim …

Losartan is oxidized to E3174 by cytochrome P450 2C9 (CYP2C9); it has been suggested
as a useful probe drug for CYP2C9 activity. It has also been shown to be a substrate for the …

Background: Glibenclamide is a substrate and an inhibitor of P-glycoprotein which is coded
by the gene ABCB1. Objective: To study the influence of ABCB1 C3435T gene …

Objective: A meta-analysis was performed to comprehensively evaluate the correlations
between the C3435T polymorphism of ABCB1 (the ATP-binding cassette, subfamily B …

The aim of the present study was to establish the gene frequency of six polymorphisms of
the ABCB1, CYP3A5, CYP2C19, and P2RY12 genes in a population resident of Mexico City …

Background Platinum-based doublets are the standard chemotherapy for lung cancer. The
identification of markers associated with drug toxicity may improve the success of the …

Objectives: The aim of study was to determine the relationship between this SNPs in
postmenopausal women with breast cancer 3435G> A (rs1045642) polymorphism of the …

Lopinavir and ritonavir are substrates of permeability glycoprotein encoded by ABCB1. The
efficacy and safety of these drugs is unknown in COVID-19 patients affected by ABCB1 …

Differences in metabolism of drugs can lead to severe toxicity or therapeutic failure. In
addition to cytochrome P450 2D6, which plays a critical role in drug metabolism, ABCB1 …

P‐glycoprotein, encoded by ABCB 1, is an ATP‐dependent drug efflux pump which exports
substances outside the cell. Some studies described connections between C3435T …