BACKGROUND Permeability glycoprotein is encoded by the ATP-binding cassette B1 gene
(ABCB1) and is an extruder of toxic metabolites in the kidney. A functional common …

Objective: Many studies have focused on the association between the ABCB1 3435C> T
polymorphism and colorectal cancer (CRC) risk. However, the results were conflicting. The …

Inherited differences in xenobiotic transport and metabolism may play an important role in
the development of adult acute myeloid leukemia (AML) and response to the chemotherapy …

What is known and objective One‐third of patients with epilepsy are resistant to anti‐
epileptic drugs (AED s). Drug‐resistant epilepsy is believed to be multifactorial involving …

Pharmacogenomics, the study of the influence of genetic factors on drug action, is
increasingly important for predicting pharmacokinetics profiles and/or adverse reactions to …

The difficulty of fine localizing the polymorphisms responsible for genotype-phenotype
correlations is emerging as an important constraint in the implementation and interpretation …

Aim We aimed to investigate the effect of the ABCB1 gene on the pharmacokinetics of
amlodipine. Methods Based on polymorphisms of the ABCB1 gene at positions 2677 and …

Cis-acting genetic variations can affect the amount and structure of mRNA/protein. Genomic
surveys indicate that polymorphisms affecting transcription and mRNA processing, including …

Objectives: ATP binding cassette (ABC) transporters are a major superfamily of drug
transporters and provide active transport of diverse substrates across cell membranes of …

Aim: To evaluate the association of ABCB1 gene polymorphisms with susceptibility to
colorectal cancer (CRC) and clinical outcomes of CRC patients with chemotherapy. Patients …