Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are
considered as last-resort antibiotic. Since the 2000s, carbapenemase producing …

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially
with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of …

Carbapenems are last-resort antibiotics used to treat multidrug-resistant bacterial infections.
Resistance to carbapenems has been designated as an urgent threat and is increasing in …

Carbapenems are used as last-resort drugs to treat infections caused by multidrug-resistant
bacteria. Despite the increasing number of reports of carbapenem-resistant …

The spread of carbapenemase-producing Gram-negative rods is an emerging global
problem. Although most infections due to carbapenemase producers are limited to …

The increasing resistance to carbapenems is an alarming threat in the fight against
multiresistant bacteria. The dissemination properties of antimicrobial resistance genes are …

Carbapenems are antibiotics of pivotal importance in human medicine, the efficacy of which
is threatened by the increasing prevalence of carbapenem-resistant Enterobacterales …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

Background The environmental role of carbapenemase-producing Enterobacteriaceae
(CPE) acquisition and infection in human disease has been described but not thoroughly …

Carbapenemase-producing bacteria cause difficult-to-treat infections related to increased
mortality in health care settings. Their occurrence has been reported in raw sewage, sewage …