Analysis of the intracellular localization of amiodarone using live single-cell mass spectrometry
K Yahata, H Mizuno, E Sugiyama, K Todoroki - Journal of Pharmaceutical …, 2021 - Elsevier
Amiodarone is a well-known antiarrhythmic drug with side effects including
phospholipidosis. However, it is not clear how amiodarone and its metabolites are localized …
phospholipidosis. However, it is not clear how amiodarone and its metabolites are localized …
Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry
SW Myung, YJ Chang, HK Min, DH Kim… - Rapid …, 2000 - Wiley Online Library
Using the high performance liquid chromatography/atmospheric pressure chemical
ionization tandem mass spectrometry (HPLC/APCI‐MS/MS) technique, together with …
ionization tandem mass spectrometry (HPLC/APCI‐MS/MS) technique, together with …
Quantitation of amiodarone and N-desethylamiodarone in single HepG2 cells by single-cell printing-liquid vortex capture-mass spectrometry
Quantitative measure of a drug and its associated metabolite (s) with single-cell resolution is
often limited by sampling throughput or other compromises that limit broad use. Here, we …
often limited by sampling throughput or other compromises that limit broad use. Here, we …
Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry
P Deng, T You, X Chen, T Yuan, H Huang… - Drug metabolism and …, 2011 - ASPET
Amiodarone is recognized as an effective drug in the treatment of arrhythmias. Previous
experiments demonstrated that mono-N-desethylamiodarone (MDEA) was the major …
experiments demonstrated that mono-N-desethylamiodarone (MDEA) was the major …
Development of an enzyme-linked immunosorbent assay for the quantification of amiodarone
T Saita, H Fujito, M Mori - Biological and Pharmaceutical Bulletin, 2002 - jstage.jst.go.jp
MATERIALS AND METHODS Equipment The IR spectrum was recorded using a Hitachi 270-
30 spectrometer (Tokyo, Japan). A proton nuclear magnetic resonance (1H-NMR) spectrum …
30 spectrometer (Tokyo, Japan). A proton nuclear magnetic resonance (1H-NMR) spectrum …
Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients
HR Ha, L Bigler, B Wendt, M Maggiorini… - European journal of …, 2005 - Elsevier
In mammals, mono-N-desethylamiodarone (MDEA) is the only known metabolite of
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …
Metabolite identification studies on amiodarone in in vitro (rat liver microsomes, rat and human liver S9 fractions) and in vivo (rat feces, urine, plasma) matrices by …
RATIONALE Several mechanisms have been anticipated for the toxicity of amiodarone, such
as oxidative stress, lipid peroxidation, phospholipidosis, free radical generation, etc …
as oxidative stress, lipid peroxidation, phospholipidosis, free radical generation, etc …
High-performance liquid chromatographic assay for amiodarone N-deethylation activity in human liver microsomes using solid-phase extraction
N Hanioka, Y Saito, A Soyama, M Ando… - … of Chromatography B, 2002 - Elsevier
A selective and sensitive assay for amiodarone N-deethylation activity in human liver
microsomes by high-performance liquid chromatography (HPLC) with UV detection is …
microsomes by high-performance liquid chromatography (HPLC) with UV detection is …
Identification and characterization of amiodarone metabolites in rats using UPLC–ESI-QTOFMS-based untargeted metabolomics approach
ES Jeong, G Kim, D Yim, KS Moon, SJ Lee… - Journal of Toxicology …, 2018 - Taylor & Francis
Amiodarone is a class III anti-arrhythmic benzofuran derivative extensively utilized in
treatment of life-threatening ventricular and supraventricular arrhythmias. However …
treatment of life-threatening ventricular and supraventricular arrhythmias. However …
Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography–tandem mass …
J Kuhn, C Götting, K Kleesiek - Journal of pharmaceutical and biomedical …, 2010 - Elsevier
A stable isotope dilution liquid chromatography–electrospray ionization tandem mass
spectrometry (LC–MS/MS) assay to measure amiodarone, the most frequently used agent …
spectrometry (LC–MS/MS) assay to measure amiodarone, the most frequently used agent …