Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis

CE Chandler, EM Harberts… - Proceedings of the …, 2020 - National Acad Sciences
Immune evasion through membrane remodeling is a hallmark of Yersinia pestis
pathogenesis. Yersinia remodels its membrane during its life cycle as it alternates between …

Characterization of Late Acyltransferase Genes of Yersinia pestis and Their Role in Temperature-Dependent Lipid A Variation

R Rebeil, RK Ernst, CO Jarrett, KN Adams… - Journal of …, 2006 - Am Soc Microbiol
Yersinia pestis is an important human pathogen that is maintained in flea-rodent enzootic
cycles in many parts of the world. During its life cycle, Y. pestis senses host-specific …

Deciphering the Acylation Pattern of Yersinia enterocolitica Lipid A

M Reinés, E Llobet, KM Dahlström… - PLoS …, 2012 - journals.plos.org
Pathogenic bacteria may modify their surface to evade the host innate immune response.
Yersinia enterocolitica modulates its lipopolysaccharide (LPS) lipid A structure, and the key …

Deletion of Yersinia pestis ail Causes Temperature-Sensitive Pleiotropic Effects, Including Cell Lysis, That Are Suppressed by Carbon Source, Cations, or Loss of …

AM Kolodziejek, CJ Hovde, GA Bohach… - Journal of …, 2021 - Am Soc Microbiol
Maintenance of phospholipid (PL) and lipopoly-or lipooligosaccharide (LPS or LOS)
asymmetry in the outer membrane (OM) of Gram-negative bacteria is essential but poorly …

Variation in lipid A structure in the pathogenic yersiniae

R Rebeil, RK Ernst, BB Gowen, SI Miller… - Molecular …, 2004 - Wiley Online Library
Important pathogens in the genus Yersinia include the plague bacillus Yersinia pestis and
two enteropathogenic species, Yersinia pseudotuberculosis and Yersinia enterocolitica. A …

Pathogenicity of Yersinia pestis synthesis of 1-dephosphorylated lipid A

W Sun, DA Six, CM Reynolds, HS Chung… - Infection and …, 2013 - Am Soc Microbiol
ABSTRACT Synthesis of Escherichia coli LpxL, which transfers a secondary laurate chain to
the 2′ position of lipid A, in Yersinia pestis produced bisphosphoryl hexa-acylated lipid A at …

LPS modification promotes maintenance of Yersinia pestis in fleas

KL Aoyagi, BD Brooks, SW Bearden… - …, 2015 - microbiologyresearch.org
Yersinia pestis, the causative agent of plague, can be transmitted by fleas by two different
mechanisms: by early-phase transmission (EPT), which occurs shortly after flea infection, or …

Structural modifications of bacterial lipopolysaccharide that facilitate gram-negative bacteria evasion of host innate immunity

M Matsuura - Frontiers in immunology, 2013 - frontiersin.org
Bacterial lipopolysaccharide (LPS), a cell wall component characteristic of Gram-negative
bacteria, is a representative pathogen-associated molecular pattern that allows mammalian …

Transcriptional regulation of the 4-amino-4-deoxy-L-arabinose biosynthetic genes in Yersinia pestis

MD Winfield, T Latifi, EA Groisman - Journal of Biological Chemistry, 2005 - ASBMB
Inducible membrane remodeling is an adaptive mechanism that enables Gram-negative
bacteria to resist killing by cationic antimicrobial peptides and to avoid eliciting an immune …

Pathogenic Yersinia enterocolitica Strains Increase the Outer Membrane Permeability in Response to Environmental Stimuli by Modulating Lipopolysaccharide …

JA Bengoechea, K Brandenburg, MD Arraiza… - Infection and …, 2003 - Am Soc Microbiol
Pathogenic biotypes of Yersinia enterocolitica (serotypes O: 3, O: 8, O: 9, and O: 13), but not
environmental biotypes (serotypes O: 5, O: 6, O: 7, 8, and O: 7, 8, 13, 19), increased their …