Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
and has worldwide impact. The etiology of the disease is complex and results from the …

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

Age-dependent cognitive decline is a major debilitating event affecting even individuals who
are otherwise healthy. Understanding the molecular basis underlying these changes may …

The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase
that can sense environmental stimuli such as growth factors, energy state, and nutrients. It is …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

Background The development of disease-modifying therapies for Alzheimer's disease is
hampered by our lack of understanding of the early pathogenic mechanisms and the lack of …

Age‐related cognitive failure is a main devastating incident affecting even healthy people.
Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric …

• Introduction• Neurodegeneration and neurofibrillary degeneration in Alzheimer's disease
brains• Dysfunction of protein synthesis mediated by mTOR‐dependent signalling in …

Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation,
and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research …

Introduction: The mTOR pathway is involved in the regulation of a wide repertoire of cellular
functions in the brain and its dysregulation is emerging as a leitmotif in a large number of …