Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Genome-wide discovery efforts have identified more than 500 genetic loci associated with
adiposity traits. The vast majority of these loci were found through large-scale meta-analyses …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …

Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta …

The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-
model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of …

Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …

Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We
performed expression quantitative trait locus (eQTL) analyses by using abdominal …

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people
world-wide. Understanding the genetic and molecular mechanisms that underlie obesity …