Background and Purpose—It is currently unclear whether midlife systemic inflammation
promotes the development of white matter (WM) abnormalities and small vessel disease in …

We examined whether the pattern of middle-to late-life systemic inflammation was
associated with white matter (WM) structural abnormalities in older adults. A total of 1532 …

Objective This investigation aimed at examining whether circulating inflammatory
biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin …

Objective Elevated inflammation is associated with worse late-life cognitive functioning and
brain health. Our goal was to examine the relationship between inflammation trajectories …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Objective: To clarify the temporal relationship between systemic inflammation and
neurodegeneration, we examined whether a higher level of circulating inflammatory markers …

Importance Small vessel cerebrovascular disease, visualized as white matter
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …

Background Diffusion tensor imaging measures of white matter (WM) microstructural
integrity appear to provide earlier indication of WM injury than WM hyperintensities; …

Abstract Background/Aims: This study investigated the relation of midlife blood pressure,
total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E, and …

Protracted systemic inflammation has been associated with adverse effects on cognition and
brain structure and may accelerate neurodegenerative disease processes; however, it is …