Associations among vascular risk factors, neuroimaging biomarkers, and cognition: preliminary analyses from the Multi‐Ethnic Study of Atherosclerosis (MESA)
SN Lockhart, CL Schaich, S Craft… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …
An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular
disease and white matter injury. Non-invasive blood markers for risk stratification and …
disease and white matter injury. Non-invasive blood markers for risk stratification and …
Carotid intima-media thickness is associated with white matter hyperintensities: the Northern Manhattan Study
D Della-Morte, C Dong, MS Markert, MSV Elkind… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Brain white matter hyperintensities (WMH) have been
associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a …
associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a …
Age‐related white matter changes
YY Xiong, V Mok - Journal of aging research, 2011 - Wiley Online Library
Age‐related white matter changes (WMC) are considered manifestation of arteriolosclerotic
small vessel disease and are related to age and vascular risk factors. Most recent studies …
small vessel disease and are related to age and vascular risk factors. Most recent studies …
Cerebral amyloid and hypertension are independently associated with white matter lesions in elderly
JA Scott, MN Braskie, D Tosun… - Frontiers in aging …, 2015 - frontiersin.org
In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are
commonly viewed as a marker of cerebral small vessel disease (SVD). SVD is due to …
commonly viewed as a marker of cerebral small vessel disease (SVD). SVD is due to …
Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
Background: Systemic inflammation is associated with ischemia and Alzheimer disease
(AD). We hypothesized that inflammatory biomarkers would be associated with …
(AD). We hypothesized that inflammatory biomarkers would be associated with …
Inflammation, cognition, and white matter in older adults: an examination by race
Objectives Non-Latino Black adults have greater risk for Alzheimer's dementia compared to
non-Latino White adults, possibly due to factors disproportionally affecting Black adults …
non-Latino White adults, possibly due to factors disproportionally affecting Black adults …
Microvascular brain pathology and late-life motor impairment
Objective: To test the hypothesis that microvascular brain pathology is associated with late-
life motor impairment. Methods: More than 2,500 persons participating in the Religious …
life motor impairment. Methods: More than 2,500 persons participating in the Religious …
Blood pressure control in aging predicts cerebral atrophy related to small-vessel white matter lesions
KC Kern, CB Wright, KL Bergfield… - Frontiers in aging …, 2017 - frontiersin.org
Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral
atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We …
atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We …
Neuropathologic correlates of white matter hyperintensities in a community-based cohort of older adults
Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …
vascular and neurodegenerative pathologies remains incompletely understood. Objective …