Background and Purpose—White matter changes (WMC) are a common finding on brain
imaging and are associated with an increased risk of ischemic stroke. They are most …

Cardiovascular health declines with age, increasing the risk of hypertension and elevated
heart rate in middle and old age. Here, we used multivariate techniques to investigate the …

Clinical studies have identified white matter (WM) lesions as hyperintensive regions in the
MRI images of elderly patients. Since a cerebrovascular origin was attributed to such …

Background and Purpose—To clarify the role of inflammation in the pathogenesis of small
vessel disease of the brain, we investigated the association between common variation in …

Alterations in cerebrovascular structure and function may underlie the most common age-
associated cognitive, psychiatric, and neurological conditions presented by older adults …

Background: Vascular disease is associated with increased risk of dementia. Vascular
health worsens with age. We investigated the relationship between self-reported vascular …

White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel
disease (SVD) markers and are associated with cognitive decline, although they do not fully …

Forty non-demented older adults who were divided into two groups on the basis of their
cognitive status (MCI: n= 20; normal control: n= 20) underwent diffusion tensor imaging, and …

Cerebral white matter damage is not only a commonly reported consequence of healthy
aging, but is also associated with cognitive decline and dementia. The aetiology of this …

Background and Purpose—White matter hyperintensities (WMH) and perivascular spaces
(PVS) are features of small vessel disease, found jointly on MRI of older people …