Background and Purpose—Blood pressure (BP) is a predictor of concurrent and
subsequently measured white-matter hyperintensity (WMH), but longitudinal studies of WMH …

Prior research has demonstrated links among vascular health and the occurrence of stroke,
mild cognitive decline, and dementia in older adults. However, little is known about whether …

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known
about if and how risk exposure in early adulthood influences late-life brain health. Objective …

We investigated progression and interrelationships of cerebral small vessel disease (cSVD)
markers. This population-based cohort study included 325 participants (age≥ 60 years) …

The occurrence of microvascular and small macrovascular lesions and Alzheimer's disease
(AD)-related pathology in the aging human brain is a well-described phenomenon. Although …

Cerebral white matter lesions (WMLs) reflect small vessel disease, are common in elderly
individuals, and are associated with cognitive impairment. We sought to determine the …

Background and Objectives The goals of this work were to quantify the independent and
interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a …

Background and Purpose—White matter hyperintensity (WMH) burden is associated with
stroke and cognitive decline. Risk factors associated with the longitudinal progression of …

Hypertension, hyperlipidemia, and diabetes are increasingly prevalent with advancing age
and have been shown to cause white-matter (WM) injury that may contribute to dementia …

Objective Examine the association of white matter hyperintensities (WMH) with risk of
incident mild cognitive impairment (MCI) and rate of decline in multiple cognitive systems in …