White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease
Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …
[HTML][HTML] Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol
AGW van Norden, KF de Laat, RAR Gons… - BMC neurology, 2011 - Springer
Background Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans
of elderly people and is related to vascular risk factors and cognitive and motor impairment …
of elderly people and is related to vascular risk factors and cognitive and motor impairment …
Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: the Three-City (3C)–Dijon Magnetic …
Background—Blood pressure (BP) is recognized as a major risk factor for white matter
lesions (WMLs), but longitudinal data are scarce, and there is insufficient evidence for the …
lesions (WMLs), but longitudinal data are scarce, and there is insufficient evidence for the …
[HTML][HTML] Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National …
C Puzo, C Labriola, MA Sugarman, Y Tripodis… - Alzheimer's research & …, 2019 - Springer
Background Longitudinal investigations are needed to improve understanding of the
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …
White matter lesions and temporal lobe atrophy related to incidence of both dementia and major depression in 70‐year‐olds followed over 10 years
P Gudmundsson, PJ Olesen, M Simoni… - European journal of …, 2015 - Wiley Online Library
Background and purpose A number of studies have suggested associations between
dementia and depression in older adults. One reason could be that these disorders share …
dementia and depression in older adults. One reason could be that these disorders share …
[HTML][HTML] Increased levels of circulating angiogenic cells and signaling proteins in older adults with cerebral small vessel disease
Background: Cerebral small vessel disease (SVD) is associated with increased risk of stroke
and dementia. Progressive damage to the cerebral microvasculature may also trigger …
and dementia. Progressive damage to the cerebral microvasculature may also trigger …
Neuropathology of white matter lesions, blood–brain barrier dysfunction, and dementia
AH Hainsworth, T Minett, J Andoh, G Forster, I Bhide… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—We tested whether blood–brain barrier dysfunction in subcortical
white matter is associated with white matter abnormalities or risk of clinical dementia in older …
white matter is associated with white matter abnormalities or risk of clinical dementia in older …
Large perivascular spaces visible on magnetic resonance imaging, cerebral small vessel disease progression, and risk of dementia: the age, gene/environment …
J Ding, S Sigurðsson, PV Jónsson, G Eiriksdottir… - JAMA …, 2017 - jamanetwork.com
Importance With advancing age, an increased visibility of perivascular spaces (PVSs) on
magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of …
magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of …
Cerebral small vessel disease and the risk of dementia: a systematic review and meta-analysis of population-based evidence
Introduction Cerebral small vessel disease is increasingly linked to dementia. Methods We
systematically searched Medline, Embase, and Cochrane databases for prospective …
systematically searched Medline, Embase, and Cochrane databases for prospective …
The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment
G Tosto, ME Zimmerman, JL Hamilton… - Alzheimer's & …, 2015 - Elsevier
Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …