Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …

Background Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans
of elderly people and is related to vascular risk factors and cognitive and motor impairment …

Background—Blood pressure (BP) is recognized as a major risk factor for white matter
lesions (WMLs), but longitudinal data are scarce, and there is insufficient evidence for the …

Background Longitudinal investigations are needed to improve understanding of the
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …

Background and purpose A number of studies have suggested associations between
dementia and depression in older adults. One reason could be that these disorders share …

Background: Cerebral small vessel disease (SVD) is associated with increased risk of stroke
and dementia. Progressive damage to the cerebral microvasculature may also trigger …

Background and Purpose—We tested whether blood–brain barrier dysfunction in subcortical
white matter is associated with white matter abnormalities or risk of clinical dementia in older …

Importance With advancing age, an increased visibility of perivascular spaces (PVSs) on
magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of …

Introduction Cerebral small vessel disease is increasingly linked to dementia. Methods We
systematically searched Medline, Embase, and Cochrane databases for prospective …

Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …