The α-synuclein (SNCA) gene encoding for the presynaptic neuronal protein α-synuclein is
closely linked to Parkinson's disease (PD). Rare missense point mutations, such as the first …

Although physiological function of alpha-synuclein is not yet clearly understood,
accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of …

Background: Mutations in the α-synuclein (SNCA) gene have been shown to be responsible
for a rare familial form of Parkinson disease (PD). Furthermore, polymorphic variants in …

Familial Parkinson's disease (PD) has been linked to missense and genomic multiplication
mutations of the α‐synuclein gene (SNCA). Genetic variability within SNCA has been …

Objective Mutations in the α-synuclein-encoding gene SNCA are considered as a rare
cause of Parkinson's disease (PD). Our objective was to examine the frequency of the SNCA …

The groundbreaking discovery of mutations in the SNCA gene in a rare familial form of
Parkinson's disease (PD) has revolutionized our basic understanding of the etiology of PD …

Mutations in the SNCA gene, which encodes the α-synuclein protein, were the first
discovered genetic causes of familial parkinsonism with Lewy pathology. To date, six …

Point mutations and copy number variations in SNCA, the gene encoding α‐synuclein,
cause familial Parkinson's disease (PD). A dinucleotide polymorphism (REP1) in the SNCA …

In Parkinson disease, the second most common neurodegenerative disorder in humans,
increased alpha-synuclein (SNCA) levels are pathogenic, as evidenced by gene copy …

Abstract Parkinson's disease (PD), one of the most common human neurodegenerative
diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the …