Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …

Microglia are implicated as primarily detrimental in pain models; however, they exist across
a continuum of states that contribute to homeostasis or pathology depending on timing and …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

Neuropathic pain is a common and severely disabling state that affects millions of people
worldwide. Such pain can be experienced after nerve injury or as part of diseases that affect …

Peripheral nerve injury causes neuropathic pain accompanied by remarkable microgliosis in
the spinal cord dorsal horn. However, it is still debated whether infiltrated monocytes …

Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …

Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by
neuropathic pain, resulting in significant physical and psychological harm to a vast number …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …