Since the activity of drugs against Mycobacterium tuberculosis grown in microbiological
culture can differ from their activity against bacteria present in infected tissues, compounds …

The activity of pyrazinamide (PZA) against eight isolates of Mycobacterium tuberculosis in a
murine infection model was evaluated. M. tuberculosis isolates with various degrees of in …

Introduction: Tuberculosis is the leading cause of death from infectious disease. Current
drug therapy requires a combination of antibiotics taken over> 6 months. An urgent need for …

Murine models of M ycobacterium tuberculosis infection are essential tools in drug
discovery. Here we describe a fast standardized 9-day acute assay intended to measure the …

Methodologies for preclinical animal model testing of drugs against Mycobacterium
tuberculosis vary from laboratory to laboratory; however, it is unknown if these variations …

In preclinical testing of antituberculosis drugs, laboratory-adapted strains of Mycobacterium
tuberculosis are usually used both for in vitro and in vivo studies. However, it is unknown …

ABSTRACT A new agar medium to perform pyrazinamide (PZA) susceptibility testing with
Mycobacterium tuberculosis has been developed. This medium has an acidic pH of 6.0 …

Objectives The intracellularly surviving and slow-growing pathogen, Mycobacterium
tuberculosis, adapts the host cell environment for its active and dormant life cycle. It is …

Emerging problems with the treatment of infections caused by Mycobacterium avium and
Mycobacterium tuberculosis require the development of new models, both in vitro and in …

SETTING: Pyrazinamide (PZA) is an effective sterilising drug in tuberculosis, but its mode of
action is controversial. OBJECTIVE: To test the bactericidal activity of 1.56–100 μg/ml PZA in …