Background: Exosome (Exo)-based chemotherapeutic drug delivery systems have been
extensively investigated; however, the therapeutic potential of other subtypes of extracellular …

Exosomes are nanosized vesicles, derived from the endolysosomal compartment of cells
and can shuttle diverse biomolecules such as nucleic acids, proteins, lipids, amino acids …

Extracellular vesicles (EVs) have been found to be effective therapeutic drug delivery
vehicles in a wide range of human diseases, including cancer and neurodegenerative …

Macrophages are fundamental to promote tumorigenesis, tumor development and
metastasis, and chemotherapy resistance through modulating tumor microenvironment and …

Cancer cells, both in vivo and in vitro, have been demonstrated to release membranous
structures, defined as microvesicles or exosomes, consisting of an array of macromolecules …

Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer
biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features …

Exosomes comprise extracellular vesicles (EVs) with diameters between 30 and 150 nm.
They transfer proteins, RNA, and other molecules from cell to cell, playing an important role …

Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and
they perform as key regulators in cell-to-cell communication in normal as well as diseased …

Tumor tissues consist of tumor cells and tumor stroma, which is structured by non-tumor cells
and the extracellular matrix. Macrophages are the predominant immune cells in the tumor …

The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …