Acute kidney injury (AKI) is a major burden on health systems and may arise from multiple
initiating insults, including ischaemia‐reperfusion injury, cardiovascular surgery …

Acute kidney injury (AKI) continues to be a major therapeutic challenge. Despite significant
advances made in cellular and molecular pathophysiology of AKI, major gaps in knowledge …

Renal blood flow, local tissue perfusion and blood oxygen content are the major
determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular …

The pathogenesis of acute kidney injury (AKI), formally termed acute tubular necrosis, is
complex and, phenotypically, may range from functional dysregulation without overt …

There are unique features of renal oxygenation that render the kidney susceptible to oxygen
demand-supply mismatch and hypoxia. Renal oxygen consumption by oxidative metabolism …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Despite the identification of several of the cellular mechanisms thought to underlie the
development of acute kidney injury (AKI), the pathophysiology of AKI is still poorly …

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue
hypoxia is thought to be a major component in the development of acute renal failure in …

Renal ischemia is the most common cause of acute kidney injury (AKI) still associated with
high mortality rates of about 50% in the intensive care unit. Postischemic AKI is …

Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …