Osteoarthritis (OA) is the most prevalent degenerative joint disease affecting millions of
people worldwide. Currently, clinical nonsurgical treatments of OA are only limited to pain …

Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …

Osteoarthritis (OA) is a primarily non-inflammatory, degenerative joint disease characterized
by progressive loss of articular cartilage, subchondral bone sclerosis, osteophyte formation …

Introduction: Intra-articular (IA) drug delivery is very useful in the treatment of osteoarthritis
(OA), the most common chronic joint affliction. However, the therapeutic effect of IA …

Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

Arthritis is a kind of chronic disease that affects joints and muscles with the symptoms of joint
pain, inflammation and limited movement of joints. Among various clinical therapies, drug …

Osteoarthritis (OA） is a common orthopaedic disease in middle-aged and aged people. To
date, no disease-modifying drug is available to prevent the progression of OA. Surgical …

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

Osteoarthritis (OA) is a degenerative disease of the joints and a leading cause of physical
disability in adults. Intra‐articular (IA) therapy is a popular treatment strategy for localized …