Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common
pathogenic hallmark of multiple autoimmune diseases. Given that the IC structural features …

Autoantibody immune complexes (ICs) mediate pathogenesis in multiple autoimmune
diseases via direct interference with target function, complement fixation, and interaction …

Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin,
which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting …

Highlights•The antibody Fc domain engages immune-activating, inhibitory, and homeostatic
Fc receptors.•Fc domains are largely unaltered in existing therapeutic antibodies, whether to …

FcγRs are a crucial component of the antibody response as they mediate the cellular effector
functions in response to IgG-containing immune complexes (ICs). Therefore, they also play a …

The in vivo biological activities of IgG antibodies result from their bifunctional nature, in
which antigen recognition by the Fab is coupled to the effector and immunomodulatory …

Self-reactive antibodies represent a significant force in autoimmune disease induction. In
antibody-dependent autoimmune syndromes such as immune thrombocytopenia (ITP) …

The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of
which isotype to pursue for development of a particular therapeutic antibody important in …

Patients with immune thrombocytopenia (ITP) commonly have antiplatelet antibodies that
cause thrombocytopenia through Fcγ receptors (FcγRs). Antibodies specific for FcγRs …