The PI3K-Akt-FoxO1 pathway contributes to the actions of insulin and leptin in several cell
types, including neurons in the CNS. However, identifying these actions in chemically …

Foxg1 is an ancient transcription factor gene orchestrating a number of neurodevelopmental
processes taking place in the rostral brain. In this study, we investigated its impact on …

The neural crest (NC) is a transient embryonic stem cell-like population characterized by its
multipotency and broad developmental potential. Here, we perform NC-specific …

Introduction Basic helix-loop-helix (bHLH) transcription factors are expressed in various
organs and are involved in diverse developmental processes. The mouse atonal homolog 8 …

Understanding the molecular mechanisms of stem cell maintenance is crucial for the
ultimate goal of manipulating stem cells for the treatment of disease. Foxd3 is required early …

Neural stem cells (NSCs) persist over the lifespan of mammals to give rise to committed
progenitors and their differentiated cells in order to maintain the brain homeostasis. To this …

Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental diseases.
It is important to characterize the cell types that express Foxp1 and Foxp2 in the brain. Foxp1 …

Neural crest‐derived stem cells (NCSCs) are tissue‐specific stem cells derived from
multipotent neural crest cells. NCSCs are present in some adult tissues such as dorsal root …

Maternal diabetes induces neural tube defects by suppressing neurogenesis in the
developing neuroepithelium. Our recent study further revealed that high glucose inhibited …

New cells are continuously generated from immature proliferating cells in the adult brain in
two neurogenic niches known as the subgranular zone (SGZ) of the dentate gyrus (DG) of …