Hepatic IGF2/H19 Epigenetic Alteration Induced Glucose Intolerance in Gestational Diabetes Mellitus Offspring via FoxO1 Mediation

Y Jiang, H Zhu, Z Chen, YC Yu, XH Guo… - Frontiers in …, 2022 - frontiersin.org
Objective The offspring of women with gestational diabetes mellitus (GDM) have a high
predisposition to developing type 2 diabetes during childhood and adulthood. The aim of the …

UCP2 regulates embryonic neurogenesis via ROS-mediated Yap alternation in the developing neocortex

F Ji, T Shen, W Zou, J Jiao - Stem cells, 2017 - academic.oup.com
Mitochondrial metabolism is a fundamental process in tissue development. How this process
play functions in embryonic neurogenesis remains largely unknown. Here, we show that …

COUP-TF1 modulates thyroid hormone action in an embryonic stem-cell model of cortical pyramidal neuronal differentiation

X Teng, YY Liu, W Teng, GA Brent - Thyroid, 2018 - liebertpub.com
Background: Thyroid hormone is critical for normal brain development and acts in a spatial
and temporal specific pattern. Thyroid hormone excess, or deficiency, can lead to …

Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL/6J mice

S Ji, W Zhou, X Li, S Liu, F Wang, X Li, T Zhao… - Cell Death & …, 2019 - nature.com
Offspring of mothers with hyperglycemia during pregnancy have a higher incidence of long-
term neuropsychiatric disorders than offspring from a normal pregnancy, indicating that …

Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre–Expressing Neurons

H Ren, L Plum-Morschel, R Gutierrez-Juarez, TY Lu… - Diabetes, 2013 - Am Diabetes Assoc
Successful development of antiobesity agents requires detailed knowledge of neural
pathways controlling body weight, eating behavior, and peripheral metabolism. Genetic …

Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS

DL Rousso, CA Pearson, ZB Gaber, A Miquelajauregui… - Neuron, 2012 - cell.com
Neuroepithelial attachments at adherens junctions are essential for the self-renewal of
neural stem and progenitor cells and the polarized organization of the developing central …

FOXO in neural cells and diseases of the nervous system

EE Santo, J Paik - Current topics in developmental biology, 2018 - Elsevier
The evolutionarily conserved FOXO family of transcription factors has emerged as a
significant arbiter of neural cell fate and function in mammals. From the neural stem cell …

[HTML][HTML] Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression

T Kumamoto, K Toma, WL McKenna, T Kasukawa… - Cell reports, 2013 - cell.com
The specification of neuronal subtypes in the cerebral cortex proceeds in a temporal
manner; however, the regulation of the transitions between the sequentially generated …

The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate

M Dottori, MK Gross, P Labosky, M Goulding - 2001 - journals.biologists.com
The neural crest is a migratory cell population that gives rise to multiple cell types in the
vertebrate embryo. The intrinsic determinants that segregate neural crest cells from …

Disruption of Foxg1 impairs neural plasticity leading to social and cognitive behavioral defects

B Yu, J Liu, M Su, C Wang, H Chen, C Zhao - Molecular Brain, 2019 - Springer
The transcription factor Foxg1 is known to be continuously expressed at a high level in
mature neurons in the telencephalon, but little is known about its role in neural plasticity …