Existing therapies for major depressive disorder (MDD) have either limited efficacy and/or
poor tolerability. The present study examined the effects of duloxetine, a potent and …

Major depressive disorder (MDD) is one of the most disabling disorders. Antidepressant
pharmacotherapy is currently effective in approximately 70% of all treated cases; the …

OBJECTIVE:: This analysis assessed the incidence, severity, onset, and duration of nausea
among patients with major depressive disorder (MDD) treated with the new antidepressant …

Background: Depression is a chronic disease consisting of emotional/psychological and
physical symptoms. Emotional symptoms have been shown to respond to currently available …

Introduction The optimal dose of duloxetine in the management of fibromyalgia remains still
controversial. Therefore, a systematic review and meta-analysis to investigate efficacy and …

BACKGROUND: While some studies have suggested sex differences in the efficacy of
antidepressant medications, there have been few investigations into potential sex …

Background Postoperative pain is common and may be severe. Postoperative
administration of non‐steroidal anti‐inflammatory drugs (NSAIDs) reduces patient opioid …

Purpose Perioperative pain management plays a critical role in the effort to promote
enhanced recovery after surgery (ERAS). Pain is also the most concern for patients after …

Background We conducted a systematic review and meta-analysis to assess effects of
selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake …

Objective: Painful physical symptoms are common in patients with major depressive
disorder (MDD) and can negatively affect patient outcomes. Duloxetine has demonstrated …