[PDF][PDF] Micrococcal nuclease is essential for Staphylococcus aureus biofilm formation in a murine implant infection model

AM Forson, CWK Rosman, TG Van Kooten… - … aureus nuclease: a …, 2022 - research.rug.nl
Advancements in contemporary medicine have led to an increasing life expectancy, which
has broadened the application of biomaterial implants. As each implant procedure has an …

[HTML][HTML] Micrococcal Nuclease stimulates Staphylococcus aureus Biofilm Formation in a Murine Implant Infection Model

AM Forson, CWK Rosman, TG van Kooten… - Frontiers in Cellular …, 2022 - frontiersin.org
Advancements in contemporary medicine have led to an increasing life expectancy which
has broadened the application of biomaterial implants. As each implant procedure has an …

Staphylococcus aureus nuclease: a target for infection detection and biofilm prevention

C Rosman - 2022 - research.rug.nl
The usage of biomedical implants is currently rapidly increasing due to ageing populations.
Consequently, the number of biomaterial-associated infections increases, which challenges …

Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant Staphylococcus aureus USA300

JB Kaplan, AR Horswill - Msphere, 2024 - Am Soc Microbiol
Biofilm formation is an important virulence factor for methicillin-resistant Staphylococcus
aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of …

[HTML][HTML] Interactions between macrophages and biofilm during Staphylococcus aureus-associated implant infection: difficulties and solutions

M Li, J Yu, G Guo, H Shen - Journal of Innate Immunity, 2023 - karger.com
Staphylococcus aureus (S. aureus) biofilm is the major cause of failure of implant infection
treatment that results in heavy social and economic burden on individuals, families, and …

[HTML][HTML] Thermonucleases Contribute to Staphylococcus aureus Biofilm Formation in Implant-Associated Infections–A Redundant and Complementary Story

J Yu, F Jiang, F Zhang, M Hamushan, J Du… - Frontiers in …, 2021 - frontiersin.org
Biofilms formed by Staphylococcus aureus are one of the predominant causes of implant-
associated infections (IAIs). Previous studies have found that S. aureus nucleases nuc1 and …

Biofilms and biocompatibility: discovering alternative targets for preventing biomaterial-associated infections

A Forson - 2022 - research.rug.nl
Medical implants are increasingly being utilised to either restore function after injury or
disease. This has presented two main challenges that threaten long-term implant …

[HTML][HTML] Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus

CWK Rosman, HC van der Mei, J Sjollema - Scientific Reports, 2021 - nature.com
A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus. This
pathogen produces a protective biofilm, making eradication difficult. Biofilms are composed …

[PDF][PDF] Real-time quantification of matrix metalloproteinase and integrin αvβ3 expression during biomaterial-associated infection in a murine model

S Daghighi, J Sjollema, RJ Dijkstra, V Jaspers… - Eur Cell …, 2014 - research.rug.nl
Biomaterial implants increase the risk of microbial infections due to the biofilm mode of
growth of infecting bacteria on implant materials, in which bacteria are protected against …

[HTML][HTML] Streptokinase Treatment Reverses Biofilm-Associated Antibiotic Resistance in Staphylococcus aureus

NP Jørgensen, N Zobek, C Dreier, J Haaber, H Ingmer… - Microorganisms, 2016 - mdpi.com
Biofilms formed by Staphylococcus aureus is a serious complication to the use of medical
implants. A central part of the pathogenesis relies on S. aureus' ability to adhere to host …