New anti-tuberculosis drugs and regimens: 2015 update

L D'Ambrosio, R Centis, G Sotgiu, E Pontali… - ERJ Open …, 2015 - Eur Respiratory Soc
Over 480 000 cases of multidrug-resistant (MDR) tuberculosis (TB) occur every year
globally, 9% of them being affected by extensively drug-resistant (XDR) strains of …

[PDF][PDF] Treatment of tuberculosis: present status and future prospects

P Onyebujoh, A Zumla, I Ribeiro… - Bulletin of the World …, 2005 - SciELO Public Health
Over recent years, tuberculosis (TB) and disease caused by human immunodeficiency virus
(HIV) have merged in a synergistic pandemic. The number of new cases of TB is stabilizing …

[HTML][HTML] Tuberculosis eradication versus control

M Schito, D Hanna, A Zumla - International Journal of Infectious Diseases, 2017 - Elsevier
Summary According to the World Health Organization (WHO), 10.4 million people died of
tuberculosis (TB) in 2015, and the disease is now the number one cause of death from a …

[HTML][HTML] Advancing the development of new tuberculosis treatment regimens: the essential role of translational and clinical pharmacology and microbiology

KE Dooley, D Hanna, V Mave, K Eisenach… - PLoS …, 2019 - journals.plos.org
Application of clinical pharmacology best practices is essential to the efficient and rational
development of drugs. In general, knowledge gained about exposure–response …

Tuberculosis drug development: history and evolution of the mechanism-based paradigm

S Chakraborty, KY Rhee - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-
infectives research. However, only one new TB drug has entered clinical practice in the past …

Recent advances in the treatment of tuberculosis

I Motta, M Boeree, D Chesov, K Dheda… - Clinical Microbiology …, 2023 - Elsevier
Background Tuberculosis (TB) is a global health challenge and one of the leading causes of
death worldwide. In the last decade, the TB treatment landscape has dramatically changed …

Tuberculosis drug development: progress, challenges, and the road ahead

AM Ginsberg - Tuberculosis, 2010 - Elsevier
Tuberculosis (TB) drug development has made substantial progress in the past decade.
There are currently at least ten drugs being evaluated in clinical trials. Some belong to …

[PDF][PDF] Technical report on the pharmacokinetics and pharmacodynamics (PK

World Health Organization - 2018 - apps.who.int
With an estimated 1.7 million deaths attributed to it each year, tuberculosis (TB) is the single
leading infectious cause of death in the world. Combined chemotherapy has been the …

Tuberculosis pharmacotherapy: strategies to optimize patient care

CD Mitnick, B McGee, CA Peloquin - Expert opinion on …, 2009 - Taylor & Francis
Introduction: The treatment of tuberculosis (TB) is a mature discipline, with more than 60
years of clinical experience accrued across the globe. The requisite Multi-drug treatment of …

Tuberculosis 2015: burden, challenges and strategy for control and elimination

M Raviglione, G Sulis - Infectious disease reports, 2016 - mdpi.com
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide, accounting for
about 9.6 million new cases and 1.5 million deaths annually. The poorest and socially …