PURPOSE: The pathogenesis of 46 XX true hermaphroditism is uncertain and the role of the
SRY gene in ovotestis development has not been thoroughly evaluated. We ascertained the …

In mammals, a master gene located on the Y chromosome, the testis-determining gene SRY,
controls sex determination. SRY protein is expressed in the genital ridge before testis …

BACKGROUND: The importance of the Y chromosome in male determination hasbeen well
established for a long time. The presence of a translocation of chromosomal material …

ABSTRACT A number of genes are known to control the development of the testis but the
transcription factor SRY encoded on the Y-chromosome is considered to play the major role …

OBJECTIVE: To describe a 46, XX male whose infertility is not accounted for by a
translocation of the SRY gene to the X chromosome or to the autosomes. DESIGN: Case …

OBJECTIVE: To report a case of a 46, XX SRY-negative man with a male phenotype and
azoospermia. DESIGN: Case report. SETTING: Molecular and Cytogenetic Unit in a …

Context: Differentiation of testicular tissue in 46, XX individuals is seen either in XX males,
the majority of them with SRY gene, or in individuals, usually SRY (−), with ovotesticular …

True hermaphroditism is an uncommon form of intersexuality in which testicular and ovarian
tissue develop in the same individual. Most true hermaphrodites are 46, XX and lack SRY …

Sry, a single‐copy gene on the Y‐chromosome, triggers the fetal gonad to begin testis
differentiation in mammals. On the other hand, mutation or absence of Sry results in ovary …

XX maleness is a rare syndrome with a frequency of 1 in 20 000–25 000 males. XX males
exist in different clinical categories with ambiguous genitalia or partially to fully mature male …