miR‐181d‐5p Protects against Retinal Ganglion Cell Death after Blunt Ocular Injury by Regulating NFIA‐Medicated Astrocyte Development

J Li, J Liu, Y Zhang, X Zha, H Zhang… - Mediators of …, 2022 - Wiley Online Library
Background. Traumatic optic neuropathy (TON) refers to damage to the optic nerve resulting
from direct and indirect trauma to the head and face. One of the important pathological …

[HTML][HTML] Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy

NPB Au, CHE Ma - Frontiers in Immunology, 2022 - frontiersin.org
Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or
indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit …

JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy

X Chu, C Wang, Z Wu, L Fan, C Tao, J Lin… - Experimental Eye …, 2021 - Elsevier
Background Indirect traumatic optic neuropathy (ITON) is a major cause of permanent loss of
vision after blunt head trauma. Neuroinflammation plays a crucial role in neurodegenerative …

Diffuse traumatic axonal injury in the optic nerve does not elicit retinal ganglion cell loss

J Wang, MA Fox, JT Povlishock - Journal of Neuropathology & …, 2013 - academic.oup.com
Much of the morbidity after traumatic brain injury (TBI) is associated with traumatic axonal
injury (TAI). Although most TAI studies focus on corpus callosum white matter, the visual …

Retinal ganglion cells die by necroptotic mechanisms in a site-specific manner in a rat blunt ocular injury model

CN Thomas, AM Thompson, Z Ahmed, RJ Blanch - Cells, 2019 - mdpi.com
Closed-globe injury can cause visual loss in military and civilian populations, with retinal cell
death, including retinal ganglion cell (RGC) degeneration, leading to irreversible blindness …

Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma

Y Huan, XQ Wu, T Chen, YN Dou, B Jia… - Neural Regeneration …, 2023 - journals.lww.com
Retinal injury after blunt ocular trauma may directly affect prognosis and lead to vision loss.
To investigate the pathological changes and molecular mechanisms involved in retinal …

Retracted: Knockdown of long noncoding RNA GAS5 attenuates H2O2‐induced damage in retinal ganglion cells through upregulating miR‐124: Potential role in …

X Miao, A Liang - 2019 - Wiley Online Library
Background Optic nerve injury is one of the most common and serious complications in
traumatic brain injury (TBI). Alleviating degree of optic nerve injury is important to cure of TBI …

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells

N Kong, X Lu, B Li - BMC Molecular Biology, 2014 - Springer
Abstract Background Retinal ganglion cells (RGCs) are preferentially lost in glaucoma or
optic neuritis. In the present study, we investigated the protective effect of mircoRNA 100 …

Remote ischemic post-conditioning therapy is protective in mouse model of traumatic optic neuropathy

M Nadeem, A Kindelin, L Mahady, K Bhatia… - NeuroMolecular …, 2021 - Springer
Traumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or
direct injury to the optic nerve following blunt head trauma. TON is associated with increased …

Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury

CN Thomas, AM Thompson… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: Ocular trauma is common in civilian and military populations. Among other injuries,
closed globe blunt ocular trauma causes acute disruption of photoreceptor outer segments …