Introduction Hereditary transthyretin-mediated (hATTR) amyloidosis, a genetic disease
caused by mutations in the transthyretin gene, leads to progressive sensory and autonomic …

Background: Transthyretin (TTR) amyloidosis is a rare, life-threatening, systemic, autosomal
dominant condition occurring in adults, with two main forms: hereditary (associated with TTR …

Background Transthyretin hereditary (familial) amyloid polyneuropathy (TTR-FAP) was first
identified in Portugal in 1952 [Citation 1]. In 1984, the first report of a causative mutation …

Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is a rare, autosomal-dominant
(AD) multisystem disorder resulting from the extracellular deposition of amyloid fibrils formed …

Hereditary transthyretin (TTR)‐related amyloidosis (ATTRm amyloidosis) is an endemic/non‐
endemic, autosomal‐dominant, early‐and late‐onset, rare, progressive disorder …

Background Hereditary transthyretin-mediated amyloidosis, also known as ATTRv
amyloidosis (v for variant), is a rare, autosomal dominant, fatal disease, in which systemic …

Hereditary transthyretin (ATTRv; v for variant) amyloidosis is a rare, multisystem,
progressive, and fatal disease in which polyneuropathy is a cardinal manifestation. Due to a …

Amyloidosis is a systemic disorder characterized by extra cellular deposition of a protein-
derived material, known as amyloid, in multiple organs. Amyloidosis occurs when native or …

ABSTRACT Background Hereditary transthyretin amyloidosis (ATTRv) is a disabling and life-
threatening disease that primarily affects the nervous system and heart. Its kidney …

Amyloidosis is a collection of diseases caused by the misfolding of proteins that aggregate
into insoluble amyloid fibrils and deposit in tissues. While these fibrils may aggregate to form …