Immune dysregulation diseases are characterized by heterogeneous clinical manifestations
and may have severe disease courses. The identification of the genetic causes of these …

Regulatory T cells (Tregs) normally maintain self-tolerance. Tregs recognize “self” such that
when they are not working properly, such as in autoimmunity, the immune system can attack …

Regulatory T cells (Tregs) are key players of immune regulation/dysregulation both in
physiological and pathophysiological settings. Despite significant advances in …

MicroRNAs (miRNAs) are evolu-tionarily conserved small noncoding RNA sequences,
approximately 22 nucleotides in length, that act as negative regulators of target genes via …

Regulatory T (Treg) cells control immune activation and maintain tolerance. How Tregs
mediate their suppressive function is unclear. Here we identified a cell surface molecule …

FOXP3 is essential for the development and function of regulatory CD4+ CD25hi T (Treg)
cells. However, recent evidence suggests that FOXP3 alone is not sufficient to completely …

The main function of the immune system is to fight off potential infections, but also to
maintain its activity below a level that would trigger self-reactivity. Regulatory T cells (Tregs) …

Monogenic diseases of the immune system, also known as inborn errors of immunity, are
caused by single-gene mutations resulting in immune deficiency and dysregulation. More …

Regulatory T cells (Treg) are essential for immune balance, preventing overreactive
responses and autoimmunity. Although traditionally characterized as CD4+ CD25+ …

Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host …