DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

Enzymatic processing of DNA underlies all DNA repair, yet inappropriate DNA processing
must be avoided. In vertebrates, double-strand breaks are repaired predominantly by non …

Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

Non-homologous end joining is the major double-strand break repair (DSBR) pathway in
mammals. DNA-PK is the hub and organizer of multiple steps in non-homologous end …

DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …

Repair of DNA double-strand breaks (DSBs) is essential for genomic stability. The most
common DSB repair mechanism in human cells, non-homologous end joining (NHEJ) …

Double-strand DNA breaks are common events in eukaryotic cells, and there are two major
pathways for repairing them: homologous recombination (HR) and nonhomologous DNA …

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is
required for resistance to genotoxic agents, such as ionizing radiation, but also for proper …

Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …

In the presence of functional DNA repair pathways, DNA double-strand breaks (DSBs) are
mainly repaired by non-homologous end-joining (NHEJ) or homologous recombination …