Background CYP17A1 gene encodes P450c17 proteins, which is a key enzyme that
catalyzes the formation of sex hormones. Many clinical studies showed that sex hormones …

Abstract Background Cytochrome P450 (CYPs) participate in the mechanisms of
cardiovascular disease. The purpose of this research was to evaluate the contributions of …

Background: The relationship between CYP17A1 genetic polymorphisms and coronary
artery disease (CAD) remains unclear. The aim of the present study was to assess the …

Abstract Background The CYP17A1 gene has been identified to associate with hypertension
in Chinese population. However, the association between CYP17A1 polymorphisms and …

Background. 7‐Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic
conversion pathway leading from cholesterol to bile acids synthesis, is encoded by CYP7A1 …

Background The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is
expressed in the vascular endothelium, which metabolizes arachidonic acid into 20 …

Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based
coronary artery disease (CAD) and modify serum lipid markers. Method: We studied …

Numerous studies have evaluated the association between the CYP11B2 gene˗ 344T> C
polymorphism and coronary artery disease (CAD) risk. However, the specific association is …

Background Coronary heart disease (CHD) is a disease that seriously harms human health.
Genetic factors seriously affect the CHD susceptibility. The CYP20A1, CYP4F2 and CYP2D6 …

Background: Identifying patients with high risk of low response to statin therapy is important
for optimization of lipid-lowering therapy. Cholesterol 7α-hydroxylase, a rate-limiting enzyme …