The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …

Vascular endothelial cells are ubiquitous for their presence in each and every vessel and
unique for their multifunctional nature. A large number of endothelial functions depend to …

This commentary presents the proceedings of the symposium sponsored by Cardiovascular
Section of American Physiological Society in San Diego, CA on 12 April 2003. The major …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …

Small arteries in the body control vascular resistance, and therefore, blood pressure and
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …

Endothelial cells in vivo form an interface between flowing blood and vascular tissue,
responding to humoral and physical stimuli to secrete relaxing and contracting factors that …

Endothelial cells (ECs) constitute the innermost layer that lines all blood vessels from the
larger arteries and veins to the smallest capillaries, including the lymphatic vessels. Despite …

Elevations in cytosolic Ca 2+ concentration are the usual initial response of endothelial cells
to hormonal and chemical transmitters and to changes in physical parameters, and many …

Abstract Control of intracellular Ca2+ ([Ca2+] i) is critical to vascular smooth muscle function.
Calcium channels are the major route by which Ca2+ enters the smooth muscle cell. This …

Although acute and chronic vasoregulation is inherently driven by endothelial Ca 2+, control
and targeting of Ca 2+-dependent signals are poorly understood. Recent studies have …