Dendritic cells are the antigen presenting cells that process antigens effectively and prime
the immune system, a characteristic that have gained them the spotlights in recent years. B …

CD4+ T cells are central regulators of both humoral and cellular immune responses. There
are many subsets of CD4+ T cells, the most prominent being T‐helper 1 (Th1), Th2, Th‐17 …

Memory T cells survive throughout the lifetime of an individual and are protective upon
recall. It is not clear how memory T cells can live so long. Here, we demonstrate that at the …

Whereas the definition of B-cell memory is based on well-known cellular properties and
differentiation steps, the process of T-cell memory generation was, until recently, less well …

CD8 and B cell memory: same strategy, same signals | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

The number of memory phenotype CD8 T cells increases dramatically with aging in both
humans and mice. However, the mechanism for this is unknown. The prevailing hypothesis …

Immune tolerance to self-antigens is a complex process that utilizes multiple mechanisms
working in concert to maintain homeostasis and prevent autoimmunity. We developed a …

During a primary response to thymus dependent antigens, B cells undergo a number of
qualitative changes to become memory B cells—processes that require co‐stimulatory …

It is widely accepted that central and effector memory CD4+ T cells originate from naïve T
cells after they have encountered their cognate antigen in the setting of appropriate co …