The Antimicrobial Peptide MK58911-NH2 Acts on Planktonic, Biofilm, and Intramacrophage Cells of Cryptococcus neoformans

JL Singulani, LT Oliveira, MD Ramos… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS
patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine …

In vitro Antifungal Activity of a Novel Antimicrobial Peptide AMP-17 Against Planktonic Cells and Biofilms of Cryptococcus neoformans

L Yang, Z Tian, L Zhou, L Zhu, C Sun… - Infection and Drug …, 2022 - Taylor & Francis
Background Cryptococcus neoformans is a common human fungal pathogen in
immunocompromised people, as well as a prevalent cause of meningitis in HIV-infected …

Antifungal Potential of Synthetic Peptides against Cryptococcus neoformans: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane–Pore …

TKB Aguiar, NAS Neto, CDT Freitas, AFB Silva… - Pharmaceutics, 2022 - mdpi.com
Cryptococcus neoformans is a human-pathogenic yeast responsible for pneumonia and
meningitis, mainly in patients immunocompromised. Infections caused by C. neoformans are …

Anticryptococcal activity and mechanistic studies of short amphipathic peptides

S Aaghaz, K Sharma, IK Maurya… - Archiv der …, 2023 - Wiley Online Library
Cryptococcus neoformans, an opportunistic fungal pathogen, causes cryptococcosis in
immunocompromised persons. A series of modified L‐histidines‐containing peptides are …

Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans

A Brakel, T Grochow, S Fritsche, D Knappe… - Frontiers in …, 2024 - frontiersin.org
Background Cryptococcosis and cryptococcal meningitis, caused by Cryptococcus
neoformans infections, lead to approximately 180,000 deaths per year, primarily in …

Antifungal Peptide SP1 Damages Polysaccharide Capsule of Cryptococcus neoformans and Enhances Phagocytosis of Macrophages

Y Liu, Y Zhang, X Zhao, W Lu, Y Zhong… - Microbiology …, 2023 - Am Soc Microbiol
Cryptococcus neoformans is a fungal pathogen which causes nearly half a million deaths
worldwide each year. Under host-relevant conditions, it produces a characteristic …

Antifungal activity of peptide MSI-1 against Cryptococcus neoformans infection in vitro and in murine cryptococcal meningoencephalitis

L Ma, S Wei, X Ye, P Xu, H Chen, Z Liu, C Zhou - Peptides, 2020 - Elsevier
The development of novel antifungal agents with high efficacy, low drug tolerance and few
side effects is urgent. MSI-1 (GIWKFLKKAKKFWK-NH 2), a cationic antimicrobial peptide …

Novel antimicrobial peptide DvAMP serves as a promising antifungal agent against Cryptococcus neoformans

L Yang, Z Tian, W Zhao, J Zhang, C Tian, L Zhou… - Bioorganic …, 2023 - Elsevier
Cryptococcus neoformans is an important opportunistic human fungal pathogen that causes
cryptococcosis in immunocompromised patients. However, the number of drugs for the …

Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans

KK Sharma, IK Maurya, SI Khan… - Journal of medicinal …, 2017 - ACS Publications
The new structural classes of ultrashort peptides that exhibit potent microbicidal action have
potential as future drugs. Herein, we report that C-2 arylated histidines containing tripeptides …

Mode of action of a designed antimicrobial peptide: high potency against Cryptococcus neoformans

A Datta, V Yadav, A Ghosh, J Choi, D Bhattacharyya… - Biophysical journal, 2016 - cell.com
There is a significant need for developing compounds that kill Cryptococcus neoformans, the
fungal pathogen that causes meningoencephalitis in immunocompromised individuals …