[HTML][HTML] Dihuang-Yinzi Alleviates Cognition Deficits via Targeting Energy-Related Metabolism in an Alzheimer Mouse Model as Demonstrated by Integration of …

G Han, W Zhen, Y Dai, H Yu, D Li, T Ma - Frontiers in aging …, 2022 - frontiersin.org
Energy metabolism disturbance and the consequent reactive oxygen species (ROS)
overproduction play a key and pathogenic role in the onset and progression of Alzheimer's …

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the “brain-gut” axis through multiple …

X Gu, J Zhou, Y Zhou, H Wang, N Si, W Ren… - Alzheimer's Research & …, 2021 - Springer
Background In recent years, excellent results have suggested an association between the
“brain-gut” axis and Alzheimer's disease (AD) progression, yet the role of the “brain-gut” axis …

Modified Huang‐Lian‐Jie‐Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer's Disease

Y Liu, T Du, W Zhang, W Lu, Z Peng… - Oxidative Medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a common neurodegenerative disease, characterized by
cognitive dysfunction; however, the therapeutic strategies are not fully understood. Huang …

Explore the effects of Huang-Lian-Jie-Du-Tang on Alzheimer's disease by UPLC-QTOF/MS-based plasma metabolomics study

LM Sun, BJ Zhu, HT Cao, XY Zhang, QC Zhang… - … of pharmaceutical and …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with neither definitive
pathogenesis nor effective treatment method so far. Huang-Lian-Jie-Du-Tang (HLJDT) is a …

Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted …

WJ He, DM Cao, YB Chen, JJ Shi, T Hu… - … of Pharmaceutical and …, 2021 - Elsevier
Diabetic encephalopathy (DE) is a severe diabetic complication with cognitive dysfunction.
Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese formula, is effective for …

Integrated network pharmacology analysis and serum metabolomics to reveal the cognitive improvement effect of Bushen Tiansui formula on Alzheimer's disease

Z Zhang, P Yi, J Yang, J Huang, P Xu, M Hu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Bushen Tiansui Formula (BSTSF) is a traditional
Chinese medicine formula used clinically to treat Alzheimer's disease (AD) for many years …

Metabolic profiling deciphering the potential targets of Yi-Gan San against vascular dementia in rat

W Liao, Z Xue, X Wang, Y Bai, Y Xiao, F Zheng, F Feng… - Brain research, 2020 - Elsevier
Vascular dementia (VaD) is widely recognized as the second most common type of
dementia, yet effective treatments are still lacking. Traditional Chinese medicine Yi-Gan San …

Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and …

Q Li, C Jia, H Wu, Y Liao, K Yang, S Li, J Zhang… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline and currently there are no available treatments. Alongside the …

[HTML][HTML] Rhein relieves oxidative stress in an Aβ1-42 oligomer-burdened neuron model by activating the SIRT1/PGC-1α-regulated mitochondrial biogenesis

Z Yin, X Geng, Z Zhang, Y Wang, X Gao - Frontiers in Pharmacology, 2021 - frontiersin.org
Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of
Alzheimer's disease (AD). Emerging evidence has shown that antioxidant therapy …

Bushen-Yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via AMPK/Sirt1 signaling pathway in D-gal-induced aging rats

Y Liao, Y Lai, H Xu, L Gao, X Fu, X Wang, Q Wang… - Chinese Medicine, 2023 - Springer
Background As a major risk factor for neurodegenerative diseases, aging has become a
heavy health care burden worldwide. Age-related decline in mitochondrial function and …