[HTML][HTML] Targeted photoimmunotherapy based on photosensitizer-antibody conjugates for multiple myeloma treatment

WM Darwish, NA Bayoumi, HM El-Shershaby… - … of Photochemistry and …, 2020 - Elsevier
Despite the high in vitro efficacy of photodynamic therapeutics, lack of tumor targeting
significantly reduces their in vivo efficacy and thus limits their clinical use …

Photosensitizer-antibody conjugates for detection and therapy of cancer

G Van Dongen, GWM Visser… - Advanced drug delivery …, 2004 - Elsevier
Photodynamic therapy (PDT) is a promising approach for the treatment of superficially
localized tumors. A limitation, however, is the lack of selectivity of the photosensitizers, which …

Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy

SRG Fernandes, R Fernandes, B Sarmento… - Organic & …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of
non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality …

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

PMR Pereira, B Korsak, B Sarmento… - Organic & …, 2015 - pubs.rsc.org
Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able
to recognize and bind to tumor-associated antigens, is today one of the most attractive …

[HTML][HTML] Targeted photoimmunotherapy for cancer

A Mussini, E Uriati, P Bianchini, A Diaspro… - Biomolecular …, 2022 - degruyter.com
Photodynamic therapy (PDT) is a clinically approved procedure that can exert a curative
action against malignant cells. The treatment implies the administration of a photoactive …

[图书][B] Photodynamic targeting with photosensitizer immunoconjugates

MD Savellano - 2000 - search.proquest.com
Photosensitizer immunoconjugates (PICs) offer improved photosensitizer delivery specificity
and could broaden the applicability of photodynamic therapy (PDT) in the treatment of …

Antibody‐Targeted Photodynamic Therapy

M Deonarain, I Stamati… - Molecular and Cellular …, 2012 - Wiley Online Library
Photodynamic therapy (PDT) is a clinically approved treatment modality for cancer and
superficial lesions. It harnesses the photochemical reaction between the light‐sensitizing …

Targeted photodynamic therapy with multiply‐loaded recombinant antibody fragments

M Bhatti, G Yahioglu, LR Milgrom… - … journal of cancer, 2008 - Wiley Online Library
Current photodynamic therapy (PDT) of cancer is limited by inefficiencies involved in
specifically targeting photosensitizers to tumors. Although antibodies are being explored as …

Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapy

MB Vrouenraets, GWM Visser, C Loup… - … journal of cancer, 2000 - Wiley Online Library
Coupling of photosensitizers to tumor‐selective monoclonal antibodies (MAbs) is an
attractive option for improving the selectivity of photodynamic therapy (PDT). For this …

[HTML][HTML] Photoactive immunoconjugates for targeted photodynamic therapy of cancer

SRG Fernandes, T Mohajershojai, S Lundsten… - … of Photochemistry and …, 2023 - Elsevier
Photodynamic therapy (PDT) has been used as an alternative or as a complement of
conventional approaches for cancer treatment. In PDT, the reactive oxygen species (ROS) …