Botulinum neurotoxin type A (BoNT/A) is a potent metalloprotease that acts primarily by
specifically cleavage of presynaptic synaptosomal-associated 25 kDa (SNAP-25) …

In the motor system, botulinum toxin type A (BoNT/A) actions were classically attributed to its
well-known peripheral anticholinergic actions in neuromuscular junctions. However, the …

The central cholinergic nervous system plays an important role in cognition, with
acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type …

Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement
disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal …

Recent reports indicate that interruption of acetylcholine release by intrastriatal injection of
botulinum neurotoxin type A (BoNT/A) in a rat Parkinson's disease model reduces …

Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum
neurotoxin A (BoNT/A) is used to treat a wide variety of disorders involving peripheral nerve …

Peripheral nerve injury leads to sensory ganglion hyperexcitation, which increases
neurotransmitter release and neuropathic pain. Botulinum toxin type A (BoNT/A) regulates …

Botulinum neurotoxins (BoNTs) are extremely potent neuromuscular poisons that act
through soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) …

Botulinum neurotoxin (BoNT) inhibits the release of acetylcholine from presynaptic vesicles
through its proteinase activity cleaving the SNARE complex. Parkinson's disease (PD) is …

Abstract Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor
nerve terminals and blocks the release of acetylcholine via the specific cleavage of the …