One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino
acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also …

Solid phase peptide library screening followed by extension of a lead recognition element
for binding to a dsDNA sequence (NF binding site of IL6) using solution phase screening …

A model study of DNA-directed peptide ligation has been developed by transferring
fluorescent reporting group from small molecule thioester to a DNA strand (template DNA) in …

In our search for new dsDNA‐binding ligands, combinatorial chemistry was first applied to
select unnatural oligopeptides with moderate affinity for dsDNA. To enhance the binding …

Targeting double-stranded DNA (dsDNA) with high affinity and specificity has become a hot
topic in biochemistry and molecular biology research. Gene diagnosis and therapy, DNA …

A cationic molecular peptide beacon NAP1 functionalized with a fluorescence resonance
energy transfer-pair at its ends allows the ratiometric detection of ds-DNA with a preference …

Molecular beacon strategies using PNA are currently restricted to fluorophore attachment to
the ends of the PNA. We report the synthesis of PNA oligomers wherein fluorophores can be …

Single base-specific detection of DNA/RNA sequences is of importance in the diagnosis of
disease-associated genetic disorders or early stage cancer. This chapter introduces DNA …

Combinatorial chemistry with a newly‐developed screening procedure using
complementary fluorescein‐and rhodamine‐labelled oligonucleotides (below) has been …

We have developed a series of short DNA‐binding peptides containing newly synthesized,
unnatural as well as natural amino acid building blocks. By a combinatorial‐library …