Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

Superantigens elicit massive and often destructive immune responses by circumventing the
usual rules of antigen presentation and T-cell recognition. Rather than binding to the cleft of …

All bacterial superantigens use common structural strategies to bind to major
histocompatibility complex class II receptors, while binding the T cell antigen receptor in …

Superantigens are a class of immunostimulatory molecules produced by bacterla and
viruses. Their potent immune effects are due to their unique ability to bind to the major …

It is well recognized that toxins of Staphylococcus aureus and Streptococcus pyogenes are
responsible for a wide range of clinical conditions, although their precise mode of action …

Microbial Superantigens are a family of protein exotoxins that share the ability to trigger
excessive and aberrant activation of T cells. The best characterised are the staphylococcal …

The bacterial superantigens are protein toxins that bind to major histocompatibility complex
class II and T‐cell receptor to stimulate large numbers of T cells. The majority are produced …

Staphylococcus aureus bacteria utilize an extensive array of molecular countermeasures to
manipulate the defensive microenvironment of the infected host and colonize potentially any …

Superantigens combine with MHC class-II molecules to form the ligands that stimulate T
cells via the Vβ element of the T-cell receptor. Two groups of superantigens have been …

The binding of superantigenic bacterial toxins to MHC class II (Ia) molecules initiates the
activation of diverse immune cells including T and B lymphocytes, monocytes and natural …