Bacterial superantigens
Superantigens (SAgs) are the most powerful T cell mitogens ever discovered.
Concentrations of less than 0· 1 pg/ml of a bacterial superantigen are sufficient to stimulate …
Concentrations of less than 0· 1 pg/ml of a bacterial superantigen are sufficient to stimulate …
Superantigens and their potential role in human disease
BL Kotzin, DYM Leung, J Kappler, P Marrack - Advances in immunology, 1993 - Elsevier
Publisher Summary This chapter provides evidence that indicates a potential role for
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …
[HTML][HTML] Clarifying the mechanism of superantigen toxicity
JD Fraser - PLoS biology, 2011 - journals.plos.org
Superantigens are bacterial proteins that generate a powerful immune response by binding
to Major Histocompatibility Complex class II molecules on antigen-presenting cells and T …
to Major Histocompatibility Complex class II molecules on antigen-presenting cells and T …
Understanding the mechanism of action of bacterial superantigens from a decade of research
PM Lavoie, J Thibodeau, F Erard… - Immunological …, 1999 - Wiley Online Library
In the face of the unique diversity and plasticity of the immune system pathogenic organisms
have developed multiple mechanisms in adaptation to their hosts, including the expression …
have developed multiple mechanisms in adaptation to their hosts, including the expression …
[HTML][HTML] Staphylococcal superantigens spark host-mediated danger signals
T Krakauer, K Pradhan, BG Stiles - Frontiers in immunology, 2016 - frontiersin.org
Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …
Bacterial pyrogenic exotoxins as superantigens
M Kotb - Clinical microbiology reviews, 1995 - Am Soc Microbiol
The recent discovery of the mode of interaction between a group of microbial proteins known
as superantigens and the immune system has opened a wide area of investigation into the …
as superantigens and the immune system has opened a wide area of investigation into the …
Superantigens: just like peptides only different
The exotoxins produced by Staphylococcus aureus and Streptococcus pyogenes are
prototype molecules for the larger family of superantigens (SAGs). This family now includes …
prototype molecules for the larger family of superantigens (SAGs). This family now includes …
Bacterial superantigens-mechanism of T cell activation by the superantigens and their role in the pathogenesis of infectious diseases
T Uchiyama, XJ Yan, K Imanishi… - Microbiology and …, 1994 - jstage.jst.go.jp
It has been 6 years since the novel concept of superantigen was proposed in 1989 in the
fields which cover immunology, microbiology and the study of infectious diseases (83) …
fields which cover immunology, microbiology and the study of infectious diseases (83) …
Superantigens in human disease
HM Johnson, JK Russell, CH Pontzer - Scientific American, 1992 - JSTOR
Normally, when a person's im mune system encounters a pro tein made by a virus or other
microbe, fewer than one in"'10,000 of the white blood cells known as T lym phocytes react …
microbe, fewer than one in"'10,000 of the white blood cells known as T lym phocytes react …
Microbial superantigens: from structure to function
AC Papageorgiou, KR Acharya - Trends in microbiology, 2000 - cell.com
Superantigens are highly potent immune stimulators with a unique ability to interact
simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular …
simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular …