The Staphylococcus aureus Enterotoxin B Superantigen Induces Specific T Cell Receptor Down-regulation by Increasing Its Internalization (∗)
F Niedergang, A Hémar, CRA Hewitt, MJ Owen… - Journal of Biological …, 1995 - ASBMB
Superantigens are able to stimulate T lymphocyte populations expressing T cell antigen
receptors (TCR) belonging to particular Vβ families. Moreover, the presence of these …
receptors (TCR) belonging to particular Vβ families. Moreover, the presence of these …
Identification and Characterization of Novel Superantigens from Streptococcus pyogenes
T Proft, S Louise Moffatt, CJ Berkahn… - The Journal of …, 1999 - rupress.org
Three novel streptococcal superantigen genes (spe-g, spe-h, and spe-j) were identified from
the Streptococcus pyogenes M1 genomic database at the University of Oklahoma. A fourth …
the Streptococcus pyogenes M1 genomic database at the University of Oklahoma. A fourth …
Toxic shock syndrome and bacterial superantigens: an update
JK McCormick, JM Yarwood… - Annual Reviews in …, 2001 - annualreviews.org
▪ Abstract Toxic shock syndrome (TSS) is an acute onset illness characterized by fever, rash
formation, and hypotension that can lead to multiple organ failure and lethal shock, as well …
formation, and hypotension that can lead to multiple organ failure and lethal shock, as well …
MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their …
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …
The TCR Vβ signature of bacterial superantigens spreads with stimulus strength
Superantigens (Sags) induce large-scale stimulation of T lymphocytes by a mechanism
distinct from conventional antigen presentation, involving direct MHC binding and …
distinct from conventional antigen presentation, involving direct MHC binding and …
Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens
Similar to native peptide/MHC ligands, bacterial superantigens have been found to bind with
low affinity to the T cell receptor (TCR). It has been hypothesized that low ligand affinity is …
low affinity to the T cell receptor (TCR). It has been hypothesized that low ligand affinity is …
Superantigen recognition and interactions: functions, mechanisms and applications
AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
Structure of the superantigen Staphylococcal Enterotoxin B in complex with TCR and peptide–MHC demonstrates absence of TCR–peptide contacts
KEJ Rödström, K Elbing… - The Journal of …, 2014 - journals.aai.org
Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus, which
are able to interact with host immune receptors to induce a massive release of cytokines …
are able to interact with host immune receptors to induce a massive release of cytokines …
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …
CD28: direct and critical receptor for superantigen toxins
R Kaempfer, G Arad, R Levy, D Hillman, I Nasie… - Toxins, 2013 - mdpi.com
Every adaptive immune response requires costimulation through the B7/CD28 axis, with
CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and …
CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and …