Like other biomolecules including nucleic acid and protein, glycan plays pivotal roles in
various cellular processes. For instance, it modulates protein folding and stability, organizes …

Axons of terminally differentiated neurons in the mammalian central nervous system (CNS)
are unable to regenerate after dissection. One of the mechanisms underlying this is the …

Chondroitin sulfate (CS) and heparan sulfate (HS) are glycosaminoglycans that both bind
the receptor-type protein tyrosine phosphatase PTPRσ, affecting axonal regeneration. CS …

Biopolymers in the human body belong to three major classes: polynucleotides (DNA, RNA),
polypeptides (proteins) and polysaccharides (glycans). Although striking progress in our …

Axons in the peripheral nervous system can regenerate after injury, whereas axons in the
central nervous system (CNS) do not readily regenerate. Intrinsic regenerating capacity and …

Traumatic spinal cord injury produces long-term neurological damage, and presents a
significant public health problem with nearly 18,000 new cases per year in the US The injury …

Chondroitin sulfate proteoglycans (CSPGs) are large extracellular matrix molecules which
are highly upregulated in the glial scar after injury to the nervous system. They are mostly …

Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons
in the central nervous system (CNS), but the structural diversity of their polysaccharides has …

Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase
dramatically following a variety of CNS injuries or diseases, have long been known for their …

Following spinal cord injury (SCI), reactive astrocytes in the glial scar produce high levels of
chondroitin sulfate proteoglycans (CSPGs), which are known to inhibit axonal regeneration …