A Ni-catalyzed (4+ 2) cycloaddition of bicyclic 3-azetidinones and alkynes was developed to
access indolizidine and quinolizidine alkaloids. A key element was the development of a …

A Ni-catalyzed (4+ 2) cycloaddition of alkynes and azetidinones toward piperidinones was
used as key reaction in the enantioselective synthesis of naturally occurring indolizidine …

The poor regioselectivity of the [4+ 2] cycloaddition of 3-azetidinones with internal alkynes
bearing two alkyl substituents via nickel-catalyzed carbon–carbon activation is addressed …

An efficient and convenient procedure that generates the active Ni (0) catalyst in situ from
cheap, air stable Ni (II) precursors is developed for the [4+ 2]-cycloaddition of alkynes and 3 …

The domino aza-annulation of cyclic enaminones with maleic anhydride and maleimides
was investigated, and selectively one-step skeletally diverse synthesis of each alkaloid-like …

Cycloaddition reactions are attractive strategies for the rapid formation of molecular
complexity in organic synthesis, as multiple bonds are formed in a single process. To this …

A new asymmetric synthesis of bicyclic pyrazolidinones through an alkaloid-catalyzed formal
[3+ 2] cycloaddition of in situ generated ketenes and azomethine imines is described. The …

Herein we report an efficient stereoselective umpolung 1, 2-addition of Et2Zn onto α-
diketones followed by intramolecular cascade Michael cyclization. This strategy effectively …

A 19-step stereoselective total synthesis of (±)-tangutorine is described here. The total
synthesis features an intramolecular aza-[3+ 3] formal cycloaddition strategy and also a …

Summary Azetidine and, more notably, 2‐azetidinone ring systems are found in a large
number of compounds with remarkable biological and pharmacological properties. Among …