Cryptococcus neoformans is a facultative intracellular fungal pathogen. Ten-generation-old
(10GEN) C. neoformans cells are more resistant to phagocytosis and killing by …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

Upon ingestion by macrophages, Cryptococcus neoformans can survive and replicate
intracellularly unless the macrophages become classically activated. The mechanism …

Does cell age matter in virulence? The emergence of persister cells during chronic
infections is critical for persistence of infection, but little is known how this occurs. Here, we …

Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

The pathogenic fungus, Cryptococcus neoformans, is known to undergo phenotypic
variation, which affects its virulence in the host. Recent investigations on C. neoformans …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. C. neoformans
resides within mature phagolysosomes where it often evades killing and replicates. C …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil
microbes such as Cryptococcus neoformans; these traits can also function in animal …

As Cryptococcus neoformans mother cells generationally age, their cell walls become
thicker and cell-wall associated virulence factors are upregulated. Antiphagocytic protein 1 …