Cellular accumulation of amiodarone and desethylamiodarone in cultured human cells: Consequences of drug accumulation on cellular lipid metabolism and plasma …
UE Honegger, RD Zuehlke, I Scuntaro… - Biochemical …, 1993 - Elsevier
Amiodarone (AMIO), a potent antiarrhythmic drug, is clinically widely used despite its
frequent side effects after chronic administration. These side effects coincide with an …
frequent side effects after chronic administration. These side effects coincide with an …
Accumulation of amiodarone and desethylamiodarone by rat alveolar macrophages in cell culture
JM Antonini, MJ Reasor - Biochemical pharmacology, 1991 - Elsevier
Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …
Vitamin E reduces accumulation of amiodarone and desethylamiodarone and inhibits phospholipidosis in cultured human cells
UE Honegger, I Scuntaro, UN Wiesmann - Biochemical pharmacology, 1995 - Elsevier
Chronic administration of amiodarone (AMIO), widely used by clinicians for the treatment of
therapy-resistant cardiac arrhythmias, is frequently associated with serious side-effects …
therapy-resistant cardiac arrhythmias, is frequently associated with serious side-effects …
Amiodarone toxicity: II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats
R Kannan, JSM Sarma, M Guha… - Toxicological …, 1991 - academic.oup.com
The contribution of desethylamiodarone (DEA), principal metabolite of the antiarrhythmic
drug amiodarone, to the major side effects of amiodarone is unclear. The effects of repeated …
drug amiodarone, to the major side effects of amiodarone is unclear. The effects of repeated …
Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats.
PA Wyss, MJ Moor, MH Bickel - Journal of Pharmacology and Experimental …, 1990 - ASPET
In order to better understand the pharmacokinetic differences between acute and chronic
regimens of the basic lipophilic antiarrhythmic, amiodarone (AM), a mass-balanced single …
regimens of the basic lipophilic antiarrhythmic, amiodarone (AM), a mass-balanced single …
In vitro metabolism of amiodarone by rabbit and rat liver and small intestine.
RA Young, HM Mehendale - Drug metabolism and disposition, 1986 - ASPET
The present studies were designed to investigate whether amiodarone (Am) is metabolized
in the major organs and tissues of the rat and rabbit. Incubations using Am and tissue …
in the major organs and tissues of the rat and rabbit. Incubations using Am and tissue …
The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat
A Shayeganpour, H Korashy, JP Patel… - International Journal of …, 2008 - Elsevier
The tissue distribution and hepatic microsomal metabolism of amiodarone were studied in a
hyperlipidemic rat model. Rats were rendered hyperlipidemic by the intraperitoneal injection …
hyperlipidemic rat model. Rats were rendered hyperlipidemic by the intraperitoneal injection …
Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats
R Kannan, JSM Sarma, M Guha… - Toxicological …, 1989 - academic.oup.com
Pulmonary and hepatotoxicity arc the two major side effects of chronic amiodarone therapy.
We studied the accumulation of amiodarone and its principal metabolite …
We studied the accumulation of amiodarone and its principal metabolite …
[PDF][PDF] Tissue uptake and metabolism of amiodarone after chronic administration in rabbits.
R Kannan, S Miller, BN Singh - Drug metabolism and disposition, 1985 - Citeseer
This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …
Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages.
MJ Reasor - Research communications in chemical pathology and …, 1991 - europepmc.org
Amiodarone is an antiarrhythmic drug that concentrates in the lungs and can cause
pulmonary damage in humans. The purpose of the present study was to examine the …
pulmonary damage in humans. The purpose of the present study was to examine the …
相关搜索
- amiodarone and desethylamiodarone drug accumulation
- cell culture accumulation of amiodarone
- metabolism of amiodarone chronic administration
- desethylamiodarone in serum measurement of amiodarone
- metabolism of amiodarone tissue uptake
- metabolism of amiodarone experimental hyperlipidemia
- amiodarone and desethylamiodarone cellular accumulation
- amiodarone and desethylamiodarone cell culture
- metabolism of amiodarone tissue distribution