Amiodarone (AMIO), a potent antiarrhythmic drug, is clinically widely used despite its
frequent side effects after chronic administration. These side effects coincide with an …

Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …

Chronic administration of amiodarone (AMIO), widely used by clinicians for the treatment of
therapy-resistant cardiac arrhythmias, is frequently associated with serious side-effects …

The contribution of desethylamiodarone (DEA), principal metabolite of the antiarrhythmic
drug amiodarone, to the major side effects of amiodarone is unclear. The effects of repeated …

In order to better understand the pharmacokinetic differences between acute and chronic
regimens of the basic lipophilic antiarrhythmic, amiodarone (AM), a mass-balanced single …

The present studies were designed to investigate whether amiodarone (Am) is metabolized
in the major organs and tissues of the rat and rabbit. Incubations using Am and tissue …

The tissue distribution and hepatic microsomal metabolism of amiodarone were studied in a
hyperlipidemic rat model. Rats were rendered hyperlipidemic by the intraperitoneal injection …

Pulmonary and hepatotoxicity arc the two major side effects of chronic amiodarone therapy.
We studied the accumulation of amiodarone and its principal metabolite …

This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …

Amiodarone is an antiarrhythmic drug that concentrates in the lungs and can cause
pulmonary damage in humans. The purpose of the present study was to examine the …