The pathogenesis of multiple sclerosis (MS) remains enigmatic and controversial. Myelin
sheaths in the central nervous system (CNS) insulate axons and allow saltatory nerve …

We have previously demonstrated that multiple sclerosis (MS) patients have abnormal
cerebrospinal fluid (CSF) levels of the key myelin-related molecules cobalamin (Cbl) …

Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow
saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple …

The purpose of this review is to highlight the new concepts of the mechanisms of multiple
sclerosis (MS) pathogenesis. For many years MS was considered to be primary …

Remyelination is a major therapeutic goal in human myelin disorders, serving to restore
function to demyelinated axons and providing neuroprotection. The target disorders that …

Axonal loss in multiple sclerosis (MS) is a key component of disease progression and
permanent neurologic disability. MS is a heterogeneous demyelinating and …

Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous
system (CNS) that affects worldwide about 2.5 million people. The morphological correlates …

Abstract Purpose of Review Multiple sclerosis (MS) is the most common demyelinating
disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both …

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …

Important insights from multiple sclerosis (MS) pathology have broadened our view of the
disease during the last years. Details of the inflammatory response as well as mechanisms …