Molecular adaptors are proteins implicated in the regulation of the cellular responses to
environmental stimuli, which can be involved in different signaling pathways depending on …

Reactive astrocytes are a hallmark of neurodegenerative disease including multiple
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …

Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration
into the central nervous system leading to inflammation, demyelination, and neuronal loss …

Th17 cells have been casually associated to the pathogenesis of autoimmune disease. We
have previously demonstrated that Rai/ShcC, a member of the Shc family of adaptor …

Reactive oxygen species (ROS) have been implicated in various types of CNS damage,
including stroke. We used a cultured astrocyte model to explore mechanisms of survival of …

Background The astrocytes in the central nervous system (CNS) exhibit morphological and
functional diversity in brain region-specific pattern. Functional alterations of reactive …

Astrocyte reactivity is a hallmark of pathological conditions in the CNS including
neurodegenerative diseases (ND) such as Alzheimer's (AD) and Huntington's (HD) …

In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated
to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of …

Astrocytes are key homeostatic cells of the central nervous system. They cooperate with
neurons at several levels, including ion and water homeostasis, chemical signal …

Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and
neurodegeneration, where reactive astrocytes can be protective or detrimental to normal …