Glial cells (astrocytes, oligodendrocytes and microglia) are critical for the central nervous
system (CNS) in both physiological and pathological conditions. With this in mind, several …

Astrocytes play several critical roles in the normal functioning of the mammalian brain,
including ion homeostasis, synapse formation, and synaptic plasticity. Following injury and …

Recent interest in astrocyte activation states has raised the fundamental question of how
these cells, normally essential for synapse and neuronal maintenance, become pathogenic …

The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …

Rationale: The neuroinflammation is necessary for glial group initiation and clearance of
damaged cell debris after nerve injury. However, the proinflammatory polarization of …

Engineered G protein‐coupled receptors (GPCRs) are commonly used in chemogenetics as
designer receptors exclusively activated by designer drugs (DREADDs). Although several …

Rai (Shc C or N-Shc) is a neuron-specific member of the family of Shc-like adaptor proteins.
Rai functions in the cytoplasmic propagation of Ret-dependent survival signals and …

Astrocytes are the most numerous cell type in the brain and perform several essential
functions in supporting neuronal metabolism and actively participating in neural circuit and …

The immune system (IS) is set to provide protection against pathogens, surveillance against
tumor cells and promotion of healing. Such functions can be efficiently performed thanks to …

Rai is a recently identified member of the family of Shc-like proteins, which are cytoplasmic
signal transducers characterized by the unique PTB-CH1-SH2 modular organization. Rai …