After injury and in disease of the central nervous system (CNS), local cells called astrocytes
respond with diverse molecular changes whose functional consequences are incompletely …

One of the earliest pathological features characterizing Alzheimer's disease (AD) is the loss
of dendritic spines. Among the many factors potentially mediating this loss of neuronal …

Focal lesions, astrogliosis, microglia activation and axonal loss in white and grey matter
define demyelinating diseases of the central nervous system (CNS), such as multiple …

Recent neuroscience research has established the adult brain as a dynamic organ having a
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …

The brain manifests cognitive deficits in aging and becomes more vulnerable to
neurodegeneration. Astrocytes play several critical roles in the brain, including synapse …

Reactive astrocytes play a potential regulatory role in sleep deprivation (SD). Paired
immunoglobulin-like receptor B (PirB) is expressed in reactive astrocytes, suggesting that …

Rac1 GTPase is implicated as a signaling mediator in various cellular events. In this study,
we show that Rac1 contributes to IFN-γ-induced inflammatory responses in rat astrocytes …

Up to approximately 70% of cancer survivors report persistent deficits in memory, attention,
speed of information processing, multi-tasking, and mental health functioning, a series of …

Astrocytes respond to injury, infection, and inflammation in the central nervous system by
acquiring reactive states in which they may become dysfunctional and contribute to disease …

Abstract The small RhoGTPase Rac1 is implicated in a variety of events related to actin
cytoskeleton rearrangement. Remarkably, another event that is completely different from …