The protein kinase WNK1 (with-no-lysine 1) influences trafficking of ion and small-molecule
transporters and other membrane proteins as well as actin polymerization state. We …

Endosomal protein trafficking is an essential cellular process that is deregulated in several
diseases and targeted by pathogens. Here, we describe a role for ubiquitination in this …

WNK4, a serine/threonine kinase, plays a critical role in the expression of membrane
proteins in the cell surface; however, the underlying mechanism of WNK4 is not clear. Here …

Mutations within the WNK1 (with-no-K [Lys] kinase-1) gene cause Gordon's hypertension
syndrome. Little is known about how WNK1 is regulated. We demonstrate that WNK1 is …

Endosomal protein recycling is a fundamental cellular process important for cellular
homeostasis, signaling, and fate determination that is implicated in several diseases. WASH …

Metastasis is the major cause of mortality in patients with breast cancer. Many signaling
pathways have been linked to cancer invasiveness, but blockade of few protein components …

Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and
patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely …

With-no-lysine (WNK) kinases are a novel family of protein kinases characterized by an
atypical placement of the catalytic lysine. Mutations of 2 family members, WNK1 and WNK4 …

WNK protein kinases form a kinase subfamily expressed in multi-cellular organisms and the
human genome encodes four distinct WNK genes. Human WNK2 has been recently …

We recently showed that the Wiskott–Aldrich syndrome protein (WASP) family member,
WASH, localizes to endosomal subdomains and regulates endocytic vesicle scission in an …